Postbiotics, also called postbiotic metabolites, originate from probiotics and include inactivated cells and their bioactive components. In 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) defined postbiotics as “a preparation of inanimate microorganisms and/or their components that confer a health benefit on the host.” Totipro® Postbiotics exemplifies this concept: it is a probiotic-fermented powder rich in metabolites and structural fragments that deliver targeted benefits without relying on live bacteria. This unique composition enhances gut health by interacting with intestinal cells to strengthen barrier integrity, modulate immune responses, and support microbiota balance. Unlike traditional probiotics, Totipro® overcomes challenges of storage and stability thanks to its sealed fermentation essence, maintaining efficacy at room temperature. This makes it a safe, versatile, and scientifically advanced solution for digestive and systemic wellness.